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As extensively researched, the primary adaptive responses athletes seek during altitude sojourns include primarily the erythropoietin (EPO)-driven increase in red blood cells (or hemoglobin mass (HBmass) [1,2,3,4,5])

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Hypoxia resulting from lung injury triggers hypoxia-inducible factor-1 (HIF-1), which upregulates endothelin-1, further constricting pulmonary vessels and stressing the RV

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Alterations of protein expression of phospholamban, ZASP and plakoglobin in human atria in subgroups of seniors