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Dai X, Dharmage SC, Bowatte G, Waidyatillake NT, Perret JL, Hui J, et al

Glucose oxidation during glycolysis produces ROS that are generally held in check by the cell's antioxidant defenses, including superoxide dismutase (SOD), thioredoxin, glutathione peroxidase (GP), and catalase [115]

The 1998 version (24) views the acinar cell as the site of mounting electrophilic stress that steadily erodes methyl (CH 3 ) and thiol (SH) - principally glutathione (GSH ) - moieties, as a result of CYP induction, concurrent exposure to a toxicant that yields RXS, and insufficiency of refurbishing micronutrients (Figure 1)

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