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2 Ferroptosis: molecular features and its relevance in atherosclerosis Ferroptosis, a form of iron-dependent programmed cell death identified in 2012, is characterized by the accumulation of lipid hydroperoxides, ultimately leading to cellular damage and death ( The classical ferroptosis pathway is regulated by the Cystine/GSH/GPX4 axis

Tkalcevi VI, Cuzi S, Brajsa K, Mildner B, Bokuli A, Situm K, Perovi D, Glojnari I, Parnham MJ

Experimental studies had shown a role of insulin in neuronal survival and synaptic maintenance and there is evidence for insulin resistance in PD brains [182]