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Morning stiffness tends to be severe, and heel-striking during running aggravates symptoms significantly

They added BPC-157 to Category 2 of substances presenting significant safety risks, noting concerns about immune reactions, peptide impurities, and lack of safety data for any human use

"In concrete terms, we advise these patients to guard their physical limits and not to exceed them," said Brent Appelman, a researcher at Amsterdam UMC

10.1016/j.isci.2019.10.002 70 YapD

The trial proceeded without reported toxicity, and no lethal dose threshold (LD1) was ever established in subsequent safety testing meaning researchers administering the compound could not find a dose that caused death in even 1% of test subjects across the animal model safety work that preceded and followed the human study