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Finally, the main issues for future revisions are presented as Future Research Questions

1 Introduction Osteosarcoma (OS), a highly aggressive malignancy predominantly affecting adolescents, continues to pose significant clinical challenges due to its elevated mortality rate and propensity for recurrence and metastasis despite advancements in multimodal therapies ( Emerging as a distinct form of regulated cell death, ferroptosis diverges fundamentally from apoptosis in its biochemical execution ( + /Fe + -mediated Fenton reactions that catalyze hydrogen peroxide (H 2 O 2 ) decomposition ( Against this backdrop, Rhizoma Paridis, a traditional Chinese medicinal herb, and its major bioactive components, Rhizoma Paridis total saponins (RPTS), have attracted attention for their potent antitumor activities

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With less of this substance being produced as the body ages, L-glutathione counteracts the damaging effects of free radicals, helping to slow the aging process and prevent degenerative diseases

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