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This oxidative insult has been demonstrated to impair pancreatic -cell function and exacerbate insulin resistance, thereby contributing to the progression of T2DM [310]

Such fine modulation of movement across the epithelium demands structural components that aid this process, such as transmembrane proteins including occludin, junctional adhesion molecules, and claudin protein family members that together maintain epithelial cell basolateral polarity (Shin et al

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