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Nutlin-3-mediated activation of p53 significantly reduces the expression of SLC7A11 in HT-1080 human fibrosarcoma cells (Zhang et al., 2018)

Tissue repair Explored in preclinical research on wound healing and soft-tissue repair, drawing on animal-only studies of TB-500 and BPC-157

Studies suggest a modest increase in circulating glucose and lactate concentrations, concurrent with a reduction in the active-to-inactive ratio of glycogen synthase across multiple tissues, including liver, skeletal muscle cells, and adipose depots

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ROS-induced oxidative stress and NLRP3-activated pro-inflammatory cytokines can damage the cochlea structure of auditory hair cells and SGNs