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Hammad ASA, Sayed-Ahmed MM, Abdel Hafez SMN, Ibrahim ARN, Khalifa MMA, El-Daly M (2023) Trimetazidine alleviates paclitaxel-induced peripheral neuropathy through modulation of TLR4/p38/NF-B and klotho protein expression

doi: 10.1016/j.bbi.2015.09.013 504 TanakaSKuratsuneHHidakaYHakariyaYTatsumiK-ITakanoTet al

PDIs can also react with GSH during thiol isomerization (Jessop and Bulleid, 2004), and may directly equilibrate with thioredoxin-related transmembrane protein 3 (TMX3) (Haugstetter et al., 2005)

Explores the use of Homo-PROTACs for the chemical knockdown of cereblon, offering a novel strategy to selectively degrade cereblon and potentially enhance therapeutic approaches for diseases associated with its dysfunction