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12,13,14 CS is a fast-developing, life-threatening, clinical condition in which the overproduction of inflammatory cytokines and excessive activation of immune cells lead to complicated medical syndromes from a persistent fever, nonspecific muscle pain, and hypotension, to capillary leak syndrome, DIC, ARDS, hemophagocytic lymphohistiocytosis (HLH), multiorgan failure, and death if treatment is not adequate

Gallbladder Removal (Cholecystectomy) Acute biliary pain from gallstones, in the absence of complications, can be treated with pain relievers (Tanaja 2018)

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Anticoagulant/Antiplatelet Drugs Theoretically, alpha-lipoic acid may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs

Abouzed et al (52) demonstrated that using angiotensin receptor blockers, such as valsartan, to inhibit the RAAS and LCZ696 to inhibit neprilysin reduced liver IRI damage in a mouse model