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To validate the role of SET7/9 in this process, the authors performed knockdown experiments using short hairpin RNA (shRNA) targeting SET7/9 (50)

Its ability to increase decorin production may be the mechanism

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mTORC1 plays the major role in the regulation of the mitochondrial protein translation, moreover mTOR is an important regulator of mitochondrial turnover by regulating mitochondrial fusion and fission processes mainly deregulated in cancer and that are associated with chemotherapy resistance

Cancer 123 PoppeD.TiedeI.FritzG.BeckerC.BartschB.WirtzS.et al (2006)