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People lose a small but steady amount by gastrointestinal blood loss, sweating and by shedding cells of the skin and the mucosal lining of the gastrointestinal tract

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The first clinical trial, titled A Phase 2a, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate the Efficacy, Safety, and Tolerability of BG00012 in Combination with Methotrexate in Patients with Active RA Who Have Inadequate Response to Conventional Disease-Modifying Anti-Rheumatic Drug Therapy (NCT00810836, 20012010), was initiated by Biogen and involved 153 participants

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