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Researchers have found that high levels of homocysteine disrupt the integrity of the blood-brain barrier , which allows substances that are normally kept out of the brain to cross over and contribute to neurological problems (99-102)

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"2,4-Dinitrophenol, the inferno drug: a netnographic study of user experiences in the quest for leanness" (PDF)

Several strategies have been proposed to alleviate this damage, including cell transplantation 4,5,6,7 and gene therapy 8,9,10,11

Once activated, SIRT1 deacetylates and activates PGC-1, the master transcriptional coactivator that directly commands the cell to build new mitochondria