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A significant 50%-decrease in pyrazine yield was observed when the reaction temperature was reduced from 120 to 100 C

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Yet despite the growing evidence implicating cigarette smoking as a major cause of the rise in lung cancer and actuarial evidence by the 1950s of a significant difference in longevity between smokers and non-smokers there was no mention of smoking in any of the companys frequent ads and pamphlets on the facts about cancer

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Thanks to decades of research, we know that smoking and tobacco use can seriously affect our health