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In comparison, a study using 7 week oral administration of the glucose analog 2-deoxy-D-glucose, which blocks glycolysis and induces ketosis, in the 3xTgAD mouse model led to reduced accumulation of A and lowered lipid peroxidation and oxidative stress response proteins, but did not decrease tau hyperphosphorylation (9)

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Elevated creatinine levels within 2 weeks in patients are associated with adverse outcomes

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NRF2 activity is also regulated by the availability of many binding partners, including a group of bZIP bi-directional transcription regulators named sMaf proteins (MafF, G and K) [200, 201] which, when bound to NRF2, under OS, favor its maintenance inside the nucleus thereby enhancing its activity [202]

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This patient's wife's complaints of cough and chest tightness should be addressed, but using her symptoms to shame the patient violates the principles of nonjudgmental motivational interviewing

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