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MECP2 expression levels are directly related to GABAA-A1R receptor expression, suggesting that MECP2 may influence neurotransmission by directly regulating the expression of GABAA-A1R receptors (78)

This leads to the cleavage and translocation of AIF from the mitochondrial intermembrane space to the nucleus, phosphorylation of the histone H2A family member H2AX, mitochondrial release of the death-inducing protein Smac/direct IAP-binding protein with low PI (DIABLO), and inhibition of the anti-apoptotic protein X-linked inhibitor of apoptosis (XIAP)

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NMR experiments were performed using 15 N-labeled Syn WT in the absence and presence of either unlabeled Syn WT or Syn 1103 at a 1:1 molar ratio in PBS containing 10% (v/v) DO