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In some people, particularly older adults or those with limited protein intake, both glycine and cysteine availability may constrain glutathione synthesis

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Functionally, GPX3 exerts its antioxidant effect through the reduction of H 2 O 2 and hydroperoxides by consuming glutathione (GSH) [17]

The presence of high serum bicarbonate could indicate chronic respiratory acidosis [typical of chronic obstructive pulmonary disease (COPD)] or metabolic alkalosis (secondary to vomiting, use of thiazide diuretics, or excess mineralocorticoids) (336)

3), which promotes ferroptosis and increases sensitivity to chemotherapy ( e.g