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References Heffernan M, Summers RJ, Thorburn A, Ogru E, Gianello R, Jiang WJ, et al

These two papers established the preclinical foundation for everything that followed

Preclinical studies found that treating neuronal, nematode, or rodent AD models with NR resulted in induction of a mitochondrial stress response, including UPR mt and mitophagy, reduced proteotoxic stress, and decreased A accumulation 243