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Description

An additional mechanistical connection between the gut and brain is the stimulation of afferent neurons of the enteric nervous system (ENS) by bacteria

The APOE-TR model is a mouse knock-in model where exons 24 (comprising the mouse APOE gene) are replaced with human APOE in 129xC57BL/6 mice back-crossed to C57BL/6 mice (Sullivan et al., 1997)

PMID 17419829

Metabolite concentrations were subsequently interquantile range (IQR) filtered and analyzed using univariate ANOVA and t -tests (unpaired, unequal variance assumed) to generate the volcano plots