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3.2.1 Non-dopaminergic Drugs to Treat Levodopa-Induced Dyskinesias Amantadine is a well-established antiparkinsonian drug with multimodal dopaminergic and non-dopaminergic properties including an antagonistic effect on N -methyl-d-aspartate (NMDA) glutamate receptors [13]

Upper airway obstruction : The upper airway frequently occludes entirely or partially during a central apnoea, most likely as a result of a decline in the central drive to the muscles that dilate the upper airway