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the STEP-1 trial reported approximately 14.9 percent on semaglutide over 68 weeks

Common adverse effects include gastrointestinal symptoms (nausea, diarrhea, constipation), which typically improve with continued use

Is GDF15 a novel biomarker to predict the development of prediabetes or diabetes

Proposed Mechanism of Action In theory, the vaccine works by: Delivering mRNA instructions encoding tumour-related antigens Presenting these antigens to immune cells Activating cytotoxic T-cells Directing immune attack toward cancer cells Despite these theoretical mechanisms, several key questions remain unanswered: Which tumour antigens are targeted Which cancer types are included Whether immune activation leads to real tumour shrinkage How long the immune response lasts What side effects may occur

J Med Chem 48(8):28382846 Ni S et al (2020) Recent progress in aptamer discoveries and modifications for therapeutic applications