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Reference Evans, OBrien, Ma, Hager, Riggins, Lambert and Riechers2017

However, TGF-1 has two sides: In addition to being an inducer driving fibrotic and anti-inflammatory responses, its inactivation may also mean exacerbating proinflammatory effects, suggesting that antifibrotic intervention that directly targets TGF- may trigger other unknown risks (145)

[Google Scholar] 166.Jadavji NM, Farr TD, Lips J, Khalil AA, Boehm-Sturm P, Foddis M, Harms C, Fchtemeier M, Dirnagl U

STC2 activates PRMT5 to induce radioresistance through DNA damage repair and ferroptosis pathways in esophageal squamous cell carcinoma

As of today, no completed, published, randomized controlled human trial exists for BPC-157 in any indication