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They can develop changes to their respiratory system similar to those seen in children exposed to tobacco smoke

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However, at 6 months after the start of bupropion treatment there was no significant difference in the expired CO level (mean difference 5.73 ppm, 95% CI 18.09 to 6.63 ppm) but there was substantial heterogeneity among trials ( P = 0.003, I 2 = 83%), largely because one trial reported a higher expired CO level in the bupropion group at 6 months