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Notably, we observed lower levels of tissue coenzyme A (CoA), which has been considered to be extremely stable 10 , resulting in reduced mitochondrial functionality and metabolic rewiring

Kinetic constants were determined using 65 kDa for the molecular weight of laccase estimated by matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) MS 22

FIGURE 1 Cell culture The cell line of HRMCs was purchased from the Chinese Academy of Sciences, Shanghai Institute for Biological Sciences Cell Resource Center

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43, 44 Urotensin-II has also been shown to function as a potent vasodilator in some isolated vessels