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In a series of clinical trials (SURPASS 1-5) individuals with type 2 diabetes have shown reduction in both HbA1c (1.2 to 2.6%) and body weight (5.411.7 kg) (Nauck and D'Alessio 2022)

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The peptide does not appear to significantly alter IGF-1 levels, pose a risk for cancer progression, or induce insulin resistance

This metabolic neutrality is precisely why they combine well