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Another study demonstrated that oxidative parameters in the semen of infertile men were significantly rather higher than in fertile men, and a very high correlation was observed between oxidative parameters, sperm ROS generation, and DNA fragmentation level [49]

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359 Furthermore, the ongoing Phase 3 persevERA (NCT04546009) clinical trial investigates the efficacy of combining giredestrant and palbociclib as a first-line treatment for metastatic breast cancer