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In addition to regulating the gene expression within the cells that produce them, miRNAs can also modulate the function of other cell populations, including monocytes and macrophages, through paracrine signaling via extracellular vesicles [43]

Typical Locations Hyperpigmentation can occur anywhere on the body but is most commonly found in areas exposed to the sun, such as the face, neck, hands, and arms

In skin allergies, oxidative stress can be intensified by the weakening of endogenous antioxidant defense mechanisms ( Table 1 )

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