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In their review of the evidence, FDA scientists flag potential safety concerns and a lack of consistent data

Employed a dual-buffer exchange method to ensure the internal pH favored peptide stability while the external pH suited the gelling agent

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To further elucidate the therapeutic mechanisms underlying D-CuPs multivalent interactions, comprehensive proteomic analysis revealed two pivotal transcriptional regulators, the tumor suppressor protein p53 and histone deacetylase 7 (HDAC7) to be potential mechanistic targets