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optionally, in case X 1 is a cyclic fragment and X 2 is C(R 3 R 3a ), the order of the X 1 fragment and the X 2 fragment within L 1 may be changed and the cyclic fragment is incorporated into L 1 via two adjacent ring atoms

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However, the small minority of CBS deficiency patients carrying such mutations exhibit high plasma concentrations of total homocysteine and clinical symptoms indistinguishable from patients with variants in the catalytic domain

Gao F, Sun M, Zhang J, Chang Y, Gao W, Ma G, et al

Again, my GP gave me a weeks worth of Diazepam and returned me to the full 30mg dose of Citalopram