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While it was of additive effect on ALT, creatinine, GSH and CAT, while it was of antagonist effect on tumor volume, Casp-3, Nf-kB, p38MAPK, and cyclin D1, Table 2

Gu M, Jin Y, Gao X, Xia W, Xu T, Pan S

Similarly, the Cu chaperone ATOX1 has also been found to serve as a modulator of angiogenesis, the depletion of Atox1 inhibit the migration of vascular smooth muscle cell that is stimulated by platelet-derived growth factor (PDGF), suggesting that ATOX1 likely plays a role in vascular remodeling and tumor angiogenesis

We divided patients into three groups according to the dose escalation method: 15 mg of donepezil for 4 weeks before escalating to 23 mg (group 1), 10 mg and 23 mg on alternate days for 4 weeks before escalating (group 2), and direct escalation to 23 mg (group 3)