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Reduced renal clearance of methotrexate has been associated to increase its half-life and making leucovorin ineffective which may induce the further toxicities such as myelosuppression, mucositis and more pronounced nephrotoxicity.94 Higher plasma concentration of methotrexate significantly decreases the NADPH production and subsequent depletion of GSH that ultimately results into impaired antioxidant defense system and cellular oxidative stress.95 Jahovic et al

Participants will be asked reasons for choosing not to participate in home spirometry, and will be surveyed about their experience with home spirometry during and at the end of the study (Additional files 3 and 4)

Alves-Lopes RU, Neves KB, Silva MA, Olivon VC, Ruginsk SG, Antunes-Rodrigues J, et al

Performance on the Wisconsin card-sorting test and serum levels of glial cell line-derived neurotrophic factor in patients with major depressive disorder

glutamicum , MSH is further involved in degradation of aromatic compounds, including gentisate, 3-hydroxybenzoate, maleylpyruvate, resorcinol, and naphthalene and msh mutants were unable to grow on these substrates (Liu et al., 2013)