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There is some interest in using IGF1-LR3 to reduce the side effects of glucocorticoids and thus allow for more effective therapy[]

Similarly, in epilepsy, the role of astrocytes in regulating ion balance by modulating ion channels and neuronal communication appears to be compromised, implying that therapeutic strategies aiming to rectify these disruptions could be beneficial in controlling epileptic seizures

doi: 10.1016/j.parkreldis.2022.08.020 172 WangX

IL-20 and IL-22 are members of the IL-10 family

Accumulation of oxidized biomolecules associated with degeneration of DA neurons indicates the involvement of oxidative stress mechanisms [1], and the highly oxidizable aromatic structure of DA and its metabolites are thought to contribute to these processes [2]