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Neuroprotection of kaempferol and quercetin against rotenone involves inhibition of oxidative stress and the mitochondrial apoptotic pathway in SH-SY5Y cells

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Studies have shown that RSL3 activates the NF-B pathway, further downregulating the expression of ferroptosis-related proteins such as ATF4 and xCT ( Fer-1 is a specific ferroptosis inhibitor that prevents ferroptosis by inhibiting lipid peroxidation

Although randomized studies have not shown an overall effect on the frequency of exacerbations, a post-hoc analysis of a clinical trial reported a decrease in their severity (87) Overall, these results demonstrate that A1PI augmentation therapy offers significant benefits in slowing the progression of emphysema and improving clinical outcomes for patients with AATD, underscoring the importance of timely and continuous treatment