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Nicotine receptor stimulation promotes wake time and reduces both total sleep time and rapid eye movement sleep." [7] Effects of nicotine diagram [edit] Comparative risk assessment chart [edit] Addiction and dependence [edit] Psychological and physical dependence [edit] Nicotine, a key ingredient [35] in most e-liquids, [36] is well-recognized as one of the most addictive substances, as addictive as heroin and cocaine