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Vitamin E increases the risk of developing heart failure after myocardial infarction: Results from the GISSI-Prevenzione trial

for example, stachyose combined with Latilactobacillus sakei repairs ICC networks by increasing 5-HT and substance P (SP) levels, inhibiting expression of VIP and NOS, with significantly greater efficacy in promoting GI peristalsis than single-agent interventions (Guo et al., 2023b)

The math: a high dose of 1,000 mcg yields about 10 mcg of absorbed B12 via passive diffusion alone, safely meeting daily needs before accounting for any direct sublingual absorption