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The PD microbiota was characterized by reduced carbohydrate fermentation and butyric acid synthesis and increased proteolytic fermentation and production of harmful amino acid metabolites, including para-cresol and phenylacetylglutamine

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pLKO.1 puro was a gift from Bob Weinberg (Addgene plasmid # 8453)

It does not predict response to a specific compound but adds upstream context for the decision

Another study shows that urate administration elevated its levels in the SOD1G85R-expressing Drosophila model of familial amyotrophic lateral sclerosis (fALS) by activating the Akt signaling pathway and the catalytic subunit of glutamate-cysteine ligase (64)