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Icaritin induces paraptosis in hepatocellular carcinoma cells by targeting BHLHE40 via endoplasmic reticulum stress and mitochondrial dysfunction

Gilliet, Lausanne (Dermatologie)

Its downstream complex, the vacuolar protein sorting 34 (VSP34) complex, the III type PI3 Kinase (PIK3C3) in mammals, can phosphorylate phosphatidylinositol (PI), the main component of the cell membrane, and produce phosphatidyl inositol triphosphate (PI3P)

Glutamines role in cellular functions makes GLS inhibition an ideal candidate for combination therapy

In the latest tranche of published warning letters, the US Food and Drug Administration (FDA) has continued to go after drugmakers for marketing glucagon-like peptide-1 (GLP-1) receptor agonists and similar medications without regulatory approval