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Daily use of sunscreen can help maintain an even skin tone and reduce the risk of pigmentation issues

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HepG2 cells were obtained from European Collection of Cell Cultures (ECACC, Salisbury, United Kingdom)

In response to bacterial stimulation, Nav1.8 + nociceptive neurons release CGRP, which subsequently acts on macrophages to inhibit tumor necrosis factor (TNF) production and ultimately the recruitment of neutrophils and monocytes to the site of infection ( + sensory neurons are directly activated by the secreted perforin toxin streptococcin S (SLS) after streptococcal infection, and activated TRPV1 + sensory neurons can release CGRP, which subsequently inhibits neutrophil recruitment and bactericidal activity ( + sensory neurons can trigger a local type 17 immune response, which not only enhances the bodys defense against Candida albicans and Staphylococcus aureus but also enhances the defense ability of adjacent unstimulated skin through neural reflex arc ( Wound healing DRG sensory neurons promote wound healing by regulating neuroimmunity in a manner illustrated in Figure 3

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