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We predicted that, at higher PDI concentrations, a 1-Cys mechanism gets more predominant over a 2-Cys mechanism since, under such conditions, reduced PDI should more likely win the race of nucleophilic attack to a sulphenylated C P against the C R residue of the same GPx7 molecule (Fig

3.1.2 Expression and regulation of key enzymes Acyl-CoA synthetase long-chain family member 4 (ACSL4) and lysophosphatidylcholine acyltransferase 3 (LPCAT3) are key enzymes that modulate phospholipid synthesis and remodeling

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