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EDC/NHS) that may also alter the chemical structure of enzymes due to crosslinking

Some of the possible factors that are abundant in CS are polyaromatic hydrocarbons (PAHs) that are inducers of cytochrome P450s and are well known sources of reactive oxygen species [28]

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CYP enzymes play a critical role in this process by enabling transient and moderate AHR activation [41, 42]

Androgen/AR complex binding to antioxidative response elements (AREs) containing promoters of target genes disrupts Wnt agonist/antagonist balance involved in DPC-inductive ability, such as dickkopf-1 (DKK1), which is a specific inhibitor of Wnt coreceptors of the LRP family 29