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smashwerx bpc 157

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Description

MOTS-c modulates the FOXO transcription factors and regulates cellular senescence, the state in which aged or damaged cells stop dividing but refuse to die, instead secreting a cocktail of inflammatory signals known as the senescence-associated secretory phenotype (SASP)

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Kemp, A

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95 KitamuraK.FujiyoshiK.YamaneJ.ToyotaF.HikishimaK.NomuraT.et al (2011)

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CHALLENGES TO DEVELOPMENT In developing the second-generation amylin-analog cagrilintide there were 2 main barriers: (1) to prevent amylin protein aggregation and (2) to extend the amylin-analogs half-life

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