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[0385] The anti-ALPP/ALPPL2 antibodies described herein can be coupled directly to the radio-opaque moiety (e.g., at an available cysteine) or they can be attached to a "package" (e.g., a chelate, a liposome, a polymer microbead, a nanoparticle, etc.) carrying, containing, or comprising the radio-opaque material, e.g., as described below

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Although the absolute amount of prolactin secreted by adipose tissue is significantly lower than that produced by the anterior pituitary gland, the large number of adipocytes (especially in highly obese individuals) suggests that adipose-derived prolactin may significantly contribute to systemic prolactin production ( de novo , with its expression and secretion strongly stimulated by cyclic adenosine monophosphate (cAMP) enhancers (65)

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2020;26:e924783-1e924783-6