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Medicinal research reviews, 43: 1668-1700 (2023) Wright JW, Kawas LH, Harding JW Progress in neurobiology, 125: 26-46 (2015) Desole C, Gallo S, et al

These disruptions are associated with disease subtypes, progression rates, and clinical outcomes (334, 335, 338354, 358), and studies have shown that iron chelation therapy can delay motor neuron degeneration and extend survival in ALS mouse models (352, 355, 358) ( Figure 8 )