The net effect depends on concentration, timing, and cellular environment
Disclosures: Jeff Li: Nothing to Disclose, Katrina Jorritsma: Nothing to Disclose, Natasha Campeau: Nothing to Disclose, Agatha Vranjkovic: Nothing to Disclose, Jood Madani: Nothing to Disclose, Torki Alothaimeen: Nothing to Disclose, Angela Cheung: Nothing to Disclose, Michele Ardolino: Nothing to Disclose, Angela Crawley: Nothing to Disclose 982 MONOCYTE TRANSCRIPTOMIC LANDSCAPE AND INTER-ORGAN CROSSTALK BETWEEN THE LIVER, BRAIN AND BONE MARROW IN A MODEL OF ALCOHOL MISUSE IN AGING Marti Ortega-Ribera 1 Radhika Joshi 1 Sergi Guix-Muntet 2 Veronika Brezani 1 Prashanth Thevkar Nagesh 3 Viliam Brezani 1 Arman Patel 1 Mrigya Babuta 1 Yuan Zhuang 1 Jordi Gracia-Sancho 4 Gyongyi Szabo 5 , 1 BIDMC - Harvard Medical School, 2 IDIBAPS, 3 Beth Israel Medical Center, 4 IDIBAPS - Hospital Clnic Barcelona, 5 Beth Israel Deaconess Medical Center Background: The globally increasing aging population exhibits high vulnerability to infections due to inflammaging (basal pro-inflammatory state) and decreased efficiency to fight pathogens
Fumaric acid esters can be taken orally and have been shown to be mostly safe, with mild side effects such as flushing and gastrointestinal disturbance (Atwan 2015)
CD70_9xCD3 EIVLTQSPGTLSLSPGERATLSCRASQSVRSNYLAWYQQKPGQAPRLLIYGASS VL -scFc RATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGDLPFTFGPGTKVEIK 725
Ramasamy, and A.M
