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Interestingly, the normal endocrine levels of IGF-II do not overcome the postnatal growth restriction

Br J Clin Pharmacol 2003;56:635-8

Grant, R., Berg, J., Mestayer, R., Braidy, N., Bennett, J., Broom, S., & Watson, J

This is particularly important for individuals with conditions that interfere with B12 absorption, such as pernicious anemia, gastrointestinal disorders like celiac disease or Crohns disease, or those who have undergone certain types of gastrointestinal surgery