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Conclusion and perspective Research on lactate metabolism and lactate-derived lactylation, as core drivers of cancer initiation and progression, is gradually changing our traditional perception of lactate as a metabolic waste product. This review systematically examines the basic mechanisms of lactate metabolism, its abnormal manifestations in tumor cells, and the multiple roles of lactate in the TME

The metal ions in the class of hard Lewis acids such as K + , Ca 2+ , Mg 2+ , Fe 3+

Approximately 40% of individuals with FHI do not have an identifiable mutation in any of the genes known to be associated with FHI

Follicular regulatory helper T cells play a rather ambiguous role in regulating the humoral immune response

These hormones play a significant role in influencing the overall health and appearance of these body parts