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The vasoconstrictive effect of Ang II is even more pronounced as the vasodilatation of the RAAS axis ACE2/Ang 1-7/AT 2 R is attenuated, and the expression/activation of endothelial nitric oxide synthase (eNOS) is reduced due to OS

Upon the cleavage, positively charged primary amines are generated, facilitating the effective crossing of the nanoprobe through BBB via the adsorption-mediated transcytosis pathway, while avoiding the caveat of cationic toxicity

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