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Omega-3 fatty acids fall into this category and are one of only two known essential fatty acids for humans (the other being omega-6 fatty acids)

501 Moreover, in a phase IV clinical trial (NCT00872599), fenofibrate effectively reduced blood pressure, heart rate, and renal vascular contraction in salt-sensitive volunteers but had no significant effect on salt-resistant individuals

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70 BCKDK inhibitors are also effective in attenuating insulin resistance in mouse models of obesity, and the development of a new generation of more powerful BCKDK inhibitors is important for diseases that require inhibition of BCAA catabolism