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Iron accumulation further amplifies ROS generation through the Fenton reaction, and triggers ferroptosis through lipid peroxidation and GSH depletion in activated HSCs, thereby providing a brake on the fibrogenic response (65)

it is associated with increased risks of metabolic syndrome, diabetes, heart disease, and stroke

However, long-term effects of androgens on AKT and its downstream targets are less examined

Metabolic Benefits : This shift may enhance fat metabolism, improve insulin sensitivity, and increase energy expenditure

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