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Additionally, metformin modulates immune function and inhibits excessive inflammation, such as by reducing levels of pro-inflammatory cytokines like IL-6 and TNF-, thereby alleviating cytokine storm-induced insulin resistance (141, 142)

Since augmented glutathione contributes for chemoresistance, the expression of xCT is also associated with resistance to drugs, platinum-salts (114), and with cell death evasion (115, 116)

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bioRxiv Prepr Serv Biol 2020

[DOI] [PubMed] [Google Scholar] 55.Spracklen CN, Horikoshi M, Kim YJ, Lin K, Bragg F, Moon S, Suzuki K, Tam CHT, Tabara Y, Kwak SH, et al