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doi: 10.1161/CIRCRESAHA.115.306885 25 LuJZhaoJMengHZhangX

IGF-1 LR3 is potent and produces results for an extended period

The initial adaptive responses that occur in skeletal muscle following an increase in ROS activity induced by contractions appear to be in the antioxidant defense enzymes and the stress or heat shock proteins (HSPs), and increased muscle content of several of these proteins has been associated with significant protection against subsequent cellular damage (157, 251, 254)